Saturday, June 29, 2013

A Fantastic Cancer Voyage Chapter 1 VIII

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

One of my fondest memories as a kid is watching the movie FANTASTIC VOYAGE. In it, a group of scientists and their ultra-futuristic laser-packing “submarine” are reduced to cell size and injected into the blood vessels of a world diplomat in order to destroy a blood clot in his brain.

What would a FANTASTIC VOYAGE: Breast Cancer look like? I’m going to write a novel here, short chapter by short chapter and I’m going to include the latest research and I’m going to imagine the entire story here for your delectation. Likely it WON’T be once a month…

Dr. Olubunmi Nwagbara – Ohloo to her close friends, Dr. O to those who wouldn’t try her last name for fear of offending her. Kim Lin Ghandi, world-renowned philosopher and The Last Hope For World Peace studied a renowned breast cancer researcher and physician.

Close on Ohloo’s heels were her personal security guards – Seven Mark from the state of Minnesota and her boss, Alex Benton. Ohloo noted that he looked about fifteen and fresh from his sophomore year in high school. She lifted her tablet computer and with a few taps brought up his bio: twenty-eight, served two tours of duty, first one in the Iraq Cleanup, then the First Pakistan War, both time as a logistician – assistant at first, then chief. At first she couldn’t figure out what food and clothing had to do with guarding here. Then she dug a bit deeper and discovered that his specialty was weapons procurement. He was also a first degree black belt in some martial-sounding art called bando. She wasn’t surprised when she tried to see what kinds of training or rank Bai Zhen Xu and was blocked.

She stopped to get coffee at the hospital’s world-class coffee shop; refusing any offer of a cup made anywhere but there. She paid up a year in advance so that she would never short change herself. The moment she set foot in the place, they had her order started.

Khadija was working today, so Ohloo said, “So, what are you taking over summer?”

She grinned then groaned, “PrinPath right now. PrinPharm second summer.”

Ohloo groaned. Khadija was an on-call nurse during the school year and worked the summer in the coffee shop. Ohloo had written one of the recommendations that had helped her get into the University of Minnesota’s medical school. She made sure she checked up on her discretely . She took her coffee, noticed that Bai Zhen Xu had signaled Khadija for a coffee as well. She seemed so strictly controlled, Ohloo found it satisfying that she allowed herself one indulgence.

She headed to her own office then, planning to catch up on some paperwork and then start to map the path she would dive to attack Kim Lin Ghandi’s cancers. Kevin and Xu followed her into the outer office. Her “secretary” was a first generation Artificial Intelligence; not smart, but pleasant and polite. It was also impossible to flatter, insult, bribe or intimidate it. She was a three dimensional projection that, while she looked more or less substantial, was obviously not real.

She said, “Good morning, Doctor Nwagbara. How are you today?”

“Just fine, Gormenghast. You’re looking as transparent as usual.”

 

“Thank you, Ma’am. Your schedule is in the desk projection and your email has been sorted by urgency.”

“Thanks. Make sure my personal body guard stays out here and guards the office.”

“Yes, Ma’am. I’ll do that.”

Before either one could get closer, Gormenghast slid the door closed over their protests. Ohloo smiled. Just like her namesake, she would stand against anything short of an all-out assault.

Ohloo stopped for a moment. One wall of the office was a window that looked south over the Guggenheim Building, parking lots and the rest of the city of Rochester. It always gave her a faint feeling of vertigo when she first stepped in. She got over it instantly, but relished it for the sense of impending doom – however nonsensical.

She went to the desk and turned back to the door and scowled. She said to the man sitting in her guest seat, “How’d you manage to get past Gormenghast, your Holiness?”

The man, the blackest man she’d ever met, whose white sclera had yellowed with age, giving him the impression of having old ivory eyes set in ebony wood. He was hairless, even the eyebrows were missing, and his skin was deeply wrinkled. He said, “I’m an evangelical. We don’t go in for all that ecclesiastical nonsense.”

She lifted her chin as she sat down, passing her hand over the center of the desk to bring up a virtual work screen. She set it to opaque so the Reverend Isamar Noor was behind it and she wouldn’t have to talk to him. She didn’t want to talk to him.

“I know you don’t want to talk to me,” he said.

“You can talk to Alex. You should expect a call from him in the next few days. I am somewhat busy right now so you can see yourself out.” She knew how he got in. He’d been on the original construction crew when the Gonda Building was raised as a supervisor and so he knew the blueprints by heart and was able to go pretty much wherever he wanted to go. He’d been talking to her about whether or not her work with picomachines was God’s Work or Of The Devil. At least he’d never ranted at her. He discussed and argued. She had no idea why he was here today.

He said abruptly, “So if Kim Lin Ghandi is the incarnation of Anti-Christ and you help her  live, you may very well be labeled the Great Whore of Babylon…”

Image: http://medgadget.com/wp-content/uploads/2006/11/Fantastic-Voyage-200x290.jpg

Sunday, June 23, 2013

The Reconstruction Era – Part 4

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…
 
“It appears that the next event is breast reconstruction!”
 
Nope, STILL not it!
 
So, my wife is sitting across from me, watching golf, a bit over six days after surgery.
 
The tubes are still in – four of them for drainage of the surgical field. (It took me almost an HOUR to find the illustration above! Isn’t that crazy? But at least now you know!) Two will come out later this week, the other two until the drainage drops to near zero. They are there to clear fluid out that the body floods the incision area with. Normal it’s absorbed back into the bloodstream, but with major surgery, it overwhelms the system. The drains smooth things out and leave less behind for infection.
 
NOT that we don’t have to be concerned about infection.
 
And pain.
 
And maintenance.
 
At any rate. My wife was actually up enough yesterday to spend time with her sister and sister-in-law in a southern suburb of Minneapolis while my daughter and foster daughter went on a shopping mission to the Mall of America.
 
She was only able to stay for a couple of hours, but enjoyed herself immensely.
 
THAT of course, was in the middle of a power outage. The largest in Minnesota history...yahoo. You can bet that THAT induced a bit of neo-panic! That passed, but we’re left with a heat wave now. Several people will be stopping in to see my wife over the next few days and my daughter and I have easily taken on the role of grocery-shoppers and cooks; housekeeping and laundering; lawn-mowing and weeding; dog and cat feeding and grooming – all jobs my wife does with unstinting love.
 
All-in-all however, we’re surprised that she’s bounced back as quickly as she has. It’s not even a week yet – she went under Monday morning…she JUST said, “I can’t believe I had the surgery!”…even as I typed this. Plus, the surgeon thought she was SO concave chested that she gave her a small saline injection into the expanders – so she came back with boobs!
 
Even our daughter commented, “You’re showing a little cleavage there, Mom!”
 
So – stage two…or is it three or four?...seems to have reached some kind of completion. She is recovering and looking forward to the next step: saline into the expanders in order to stretch the skin in preparation for the implants themselves in November of December.
 
I’ll keep you posted and if you have any questions or comments, shoot them my way and I’ll try and answer them!
 

WORST POWER OUTAGE IN MINNESOTA HISTORY!

 
Like it says -- we've been out of power since Friday night. (We live in the upper left hand corner!) I'll get caught up shortly!

Guy

Saturday, June 15, 2013

BREAST CANCER RESEARCH RIGHT NOW! 11: Gene That Says, “Breast Cancer Cells? INVADE THE BODY!” Discovered

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…
 
Every month, I’ll be highlighting breast cancer research that is going on RIGHT NOW! Harvested from different websites, journals and podcasts, I’ll translate them into understandable English and share them with you. Today: http://www.sciencedaily.com/releases/2013/06/130614081714.htm (Yeah, I know, this seems to be the site that highlights cutting edge breast cancer research – there’s SO much more there, you should put it on your Favorites Bar and check it often! If you don’t get something, I CAN translate (BS in biology, 33 years of experience teaching science of all sorts, to kids of all sorts…from astronomy to zoology. I CAN help!)
 
One of the most horrifying pronouncements breast cancer survivors can hear comes AFTER the initial diagnosis: “I’m sorry, the cancer has spread.”
 
“Why?”
 
“We don’t know for certain, we only know that there are indications that you might have…bone cancer…lung cancer…brain cancer…liver cancer…”
 
The post more people have gone to on this blog is the one on brain cancer (admittedly, the reason they go there is because more people GOOGLE “brain cancer” when they have a bout of extended, unusual headaches than just about any other normal, more average diagnosis – like dehydration…), and the 4-part series on metastatic breast cancer garnered 7% of ALL the hits on this site (with 116 posts). This is a big deal!
 
So what’s new?
 
ROR1, is what.
 
Identified by a team of researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, ROR1 is a (thankfully shortened) acronym for “Receptor-tyrosine-kinase-like Orphan Receptor 1”.
 
And that is????
 
How to explain this…OK – a baby develops from conception. How do an egg cell and a sperm cell create heart, lung, and toe cells? The process of changing the sperm and egg cell into the rest of a person, is controlled by family of molecules in the growing baby called ROR1. I won’t get into the technical language regarding this protein except to say that they “live” on the surface of cells and they attract and hold lots and lots of growth controlling molecules, hormones and other molecules carrying chemical messages from other parts of the body.
 
ROR1 is also active at exactly two times in a human’s life: during the growth of the embryo and during cancer cell growth.
 
The team doing this research points out that the identification of ROR1 at these two times, “presents a singular, selective target for anti-cancer therapies that would leave normal cells unaffected.”
 
Normal cells unaffected! Can you imagine that? No more hair loss! No more muscle weakness! No more susceptibility to colds, flu, and every other disease known to humanity!
 
This is NOT a new therapy available today – but the research group suggests that “silencing expression of ROR1 reverses...and inhibits the metastatic spread of breast cancer cells in animal models. Moreover, the researchers found that treatment with a monoclonal antibody [a compound made by humans that is specifically targeted at a single, disease-causing organism. A cell poison for that organism could ride along with the compound] targeting ROR1 also could inhibit the growth and spread of highly metastatic tumors that express ROR1.”
 
In other words, they hope that women in the future diagnosed with metastatic breast cancer will have a powerful recourse that will be less invasive than any of the other.
 

Saturday, June 8, 2013

The Reconstruction Era – Part 3

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

“It appears that the next event is breast reconstruction!”

Nope – it wasn’t...

After the “Get Healthy” step, there was the pre-operation step. That was a few days ago. During that meeting, the plastic surgeon was not ONLY encouraging, but also really helpful.

It put into my mind a scene from one of my favorite movies, “Doc Hollywood”. In it (in case you haven’t seen it), the young (QUITE YOUNG), Michael J. Fox plays a doctor moving from the gang violence and drug abuse of a downtown Washington, D.C. ER.

He gets the chance to interview at a fancy-pants Plastic Surgery clinic in Beverly Hills. During his first day on the job, the owner, Dr. Halberstrom (of Halberstrom’s (Plastic Surgery) Clinic), performing an obvious liposuction, “Nobody likes to admit it, but medicine's a volume business. Ninety-nine percent of what we do is boilerplate surgery. It means we can afford the one percent that's meaningful. Disfigurements, birth defects, hare lips. Cleft palates. You live for those moments.”

This is reconstruction after breast cancer – no movie stars; no facelifts; no liposuction. What nobler cause for a plastic surgeon?

What IS “plastic surgery” and why the heck is it called that?

FIRST off, “In the term plastic surgery, the adjective plastic denotes sculpting, and derives from the Greek πλαστική (τέχνη), plastikÄ“ (tekhnÄ“), “the art of modeling” of malleable flesh.

From that, PS has a noble history, initially being used by the Indian surgeons Sushruta and Charak (in 800 BC!!!) to reconstruct noses for “resolving nasal trauma (blunt, penetrating, blast damage), congenital defect, and respiratory impediment”.

The Romans and the Greeks followed suit, then the British and the rest of Europe. The first American plastic surgeon repaired a cleft palate in 1827. During World War I, a New Zealand doctor named Harold Gillies working in London, invented many of the surgical techniques used in facial surgery today in order to rebuild the faces of soldiers injured in the war.

Two dozen other types of plastic surgery dominate the world today. In 2009, statistics were reliably gathered on plastic surgery for the first time: “The ISAPS Global Survey also establishes several important statistics with regard to the total number of board certified (or national equivalent) plastic surgeons practicing today; estimated to be 30,817. The total number of surgical procedures is projected to be 8,536,379 and the number of non-surgical procedures is estimated at 8,759,187  – bringing  the combined worldwide total of surgical and non-surgical procedures performed by board certified plastic surgeons to: 17,295,557. (This figure does not take into account surgical and non-surgical procedures performed by non-plastic surgeons.)”

As to breast reconstruction: “…dates back to the 1800s with an attempt to transplant a lipoma to a mastectomy site. Several techniques ranging from the ‘walking flap’ of Gilles to the free perforator flap using autogenous tissue for recreation of a breast ‘mound’ have been established and refined. The use of tissue expanders for breast reconstruction has also been perfected over the last three decades. Breast reconstruction, which was once admonished in the early part of the 20th century, has now become a routine choice for women undergoing breast cancer surgery.”
 
As Spock is wont to say (in both his past and present incarnations), “Fascinating.”
 

Saturday, June 1, 2013

BREAST CANCER WISDOM 2: From Others and From Life Here…

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

I love to laugh.

Laughter has saved me from dark depression more times than I can count.

So this month’s BC Wisdom comes in the form of T-SHIRTS!

There’s not much to say except I picked a couple of my favorites and provided the link to the site.

Enjoy!

The site: http://www.breastcancert-shirts.com/categories/funny-breast-cancer-tshirts?p=7

My two favorites:





Images: see above!