Sunday, October 25, 2020

Encouragement (In Suffering, Pain, and Witnessing Both…) #13: When the Battle Has Passed and All That’s Left Are the Memories

The older I get, the more suffering and pain I’ve experienced; and the more of both I stand witness to. From my wife’s (and many, many of our friends and coworkers) battle against breast cancer; to my dad’s (and the parents of many of our friends and coworkers) process as he fades away as this complex disease breaks the connections between more and more memories, I have become not only frustrated with suffering, pain, and having to watch both, I have been witness to the suffering and pain among the students I serve as a school counselor. I have become angry and sometimes paralyzed. This is my attempt to lift myself from the occasional stifling grief that darkens my days. 

My first post for these encouragement essays went up in February of 2018; that’s close to three years ago…

As I sit here typing this, Mom and Dad have been gone four years and a year-and-a-half ago respectively. I’ve mused on how glad I am that neither one had to suffer through COVID19, but the things that have had to occur because of it. They never had to witness images like this: https://images.wsj.net/im-169334?width=1280&size=1 

I know for certain my dad would have recalled a scene from a movie we watched together: https://cinematicrandomness.com/wp-content/uploads/2017/11/Andromeda-Strain-The-FM001-1024x512.png 

That was called The Andromeda Strain (1971); this is called The COVID19 Pandemic…

I’m sure they’ll make a movie out of it someday.

I could, I guess, go down the rabbit hole and relate figures and stories that are NOT encouraging. It would be easy. It certainly seems that that is the route the newsmakers have chosen – bombarding us with horror stories dramatically narrated by brave journalists risking their lives to “tell us the truth”…

Don’t get me wrong, the news my wife and I watch make CERTAIN that after a zillion hours of horror, they toss us a very thin bone of hope, tastefully edited to have a ray of sunshine in otherwise grim and dark days. All we have to do is elect Joe Biden and give the senate over to the Democratic Party and all of our troubles will be over. Great-great-grandpa Joe will take all our troubles on his shoulders and Mother Nancy will make certain that the memory of the past four years of Evil Incarnate are erased from history…

It's hard to find encouragement here – except in the actions of regular people whose political affiliation isn’t the issue. Rather their HUMANITY is the issue.

Follow the link to this article written by one Steven Vera, Chief Executive Officer of Wachusett Ventures, LLC, which operates two Connecticut and two Massachusetts nursing homes. This appeared in the April 18, 2020 issue of The CT Mirror. It’s inspiring, hopeful, and ENCOURAGING:

https://ctmirror.org/category/ct-viewpoints/a-tribute-based-on-observation-and-experience/

Image: http://www.quoteambition.com/wp-content/uploads/2017/04/encourage-quotes-destiny.jpg

Sunday, October 18, 2020

ENCORE #145! – Putting It All Together: Exercise Ain’t Magic!

From the first moment my wife discovered she had breast cancer in March of 2011, there was a deafening silence from the men I knew. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…That was four years ago – as time passed, people searching for answers stumbled across my blog and checked out what I had to say. The following entry first appeared in June 2012.

Doctors harp on exercise and this is the last time I’ll harp on it at length, too!

Despite the harping – or in my case, perversely because of it – I avoid exercise like the plague.

Even so, as I read more and more sites promoting the “exercise makes you better if you have breast cancer” meme, I found that almost none of them give any kind of evidence as to WHY exercise fights cancer and promotes healing.

So I dug into the sites and finally found some evidence supporting this wild, “Do this one weird thing…” kind of meme.

1) “The complicated nature of the physical activity variable, combined with lack of knowledge regarding possible biological mechanisms operating between physical activity and cancer, warrants further studies including controlled clinical randomized trials.”

Translation?

We haven’t got a good, clear idea of why exercise makes some kind of difference because we can’t quite dig deep enough or look small enough into the Human body to really understand this.

It seems clear that we know a few things: exercise gets rid of fat cells that make estrogen and estrogen drives cancer cell growth; exercise makes insulin more effective; exercise reduces the amount of leptin (which gives cells more cancer receptors) in your blood because you have fewer fat cells to make it; exercise suppresses the production of LH, FSH and “other ovarian hormones” like estrogen and progestogens. At MUCH lower levels, exercise can mimic the effect of the anti-cancer drug, tamoxifen; exercising means that more fat is metabolized and you don’t need as MUCH of the hormone to do the work of fat destruction so there are fewer hormones to drive cancer cell growth; exercise decreases the markers of inflammation; exercise boosts the immune system by circulating more wbcs and T cells, lowers the chemicals that cause swelling, lowers the number of fat cells which make estrogen which strengthens breast cancer cells and keeps the immune system working like this LONGER; and lastly, even the exercise of DAILY MOVEMENT can increase the effectiveness of insulin in those who are insulin resistant.

So we know that exercise is helpful in preventing and recovering from breast cancer. I guess that’s a big “duh” for me. Of course keeping the body healthy would prevent and fight breast cancer. 

But now we know the HOW – and that’s been my goal all along!

Image: https://c2.staticflickr.com/6/5527/10893068965_1d328e8f71_b.jpg


Sunday, October 11, 2020

ALZHEIMER’S RESEARCH RIGHT NOW! #10: Proteins Found In Eyeball May Be Able To Help In ALZHEIMER’S Diagnosis!

From the first moment I discovered my dad had been diagnosed with Alzheimer’s, it seemed like I was alone in this ugly place. Even ones who had loved ones suffering in this way; even though people TALKED about the disease, it felt for me like they did little more than mumble about the experience. Not one to shut up for any known reason, I added a section to this blog…

Every month, I’ll be highlighting Alzheimer’s research that is going on RIGHT NOW! Harvested from different websites, journals and podcasts, I’ll translate them into understandable English and share them with you. Today: “Biomarker indicating neurodegeneration identified in the eye”

A little over a year ago, I discovered that there was evidence that a simple eye test might be able to detect amyloids on the retina. The link to my blog post is here – and at that time there was very little information on the procedure: https://breastcancerreaper.blogspot.com/2019/08/alzheimers-research-right-now-3-what-do.html

A recent study (see link below) seems to be an extension of the research I was barely able to touch on. It seems there might be a link between what was originally a blood test and possibly finding the same proteins in the vitreous humor in the eye – that is, in the liquid that fills your eyeball to make it inflated and look sort of like a water balloon.

With almost 5.8 million Americans and 35.2 million Alzheimer’s victims worldwide – and the number is growing as science continues to extend the Human lifespan – the economic and emotional impact will only continue to grow as time passes.

Early detection might help to blunt some of the impact.

OK – let’s back up a little. How’s all of this tied to my dad’s suffering Alzheimer’s for at least four years?

It seems that, while the causes of Alzheimer’s are elusive, we do know certain things. One of those things is that the disease has SOMETHING to do with proteins called “β amyloids and tau proteins [which] are biomarkers for Alzheimer's disease…”

Huh? What are these things? OK – first of all they’re proteins. You’re made up mostly of proteins as is the hamburger you buy in the grocery store or the grilled/fried hockey pucks on bread with other stuff you can get at any fast-food joint on six continents. There a zillions of kinds of proteins though.

The two that end up in the brains of Alzheimer’s patients are the ones I mentioned above. The first one, we’re not even sure where it comes from. Researchers speculate that a large molecule of protein may bind to other proteins on the surface of cells or help cells attach to one another. Cells like nerve cells (neurons) during early development are directed to where they’re supposed to go>

Afterwards, the protein is cut by enzymes to create smaller fragments, releasing some of them outside the cell. One of them appears to have a role in making nerve cells grow. The other one, the β amyloid, is likely involved in the ability of neurons to change and adapt over time.

“Tau proteins form part of a structure called a microtubule. One of the functions of the microtubule is to help transport nutrients and other important substances from one part of the nerve cell to another.”

However, in the brains of people with Alzheimer’s disease, the proteins are “misfolded” and abnormally shaped. In this abnormal shape, they tend to clump together forming a plaque – sort of like the plaque that forms on your teeth and the dentist has to scrape off. Neither kind of plaque is good – in fact, the combination of faulty β amyloid and tau proteins appears to have something to do with the brain conditions leading to Alzheimer’s, messing with the brain’s delicate structure at a microscopic level.

Older research showed that these two proteins – together they’re called “biological markers” were evidence in blood and in a liquid that surrounds your spine (spinal fluid). While blood samples are pretty much a normal things for most of us, taking out samples of spinal fluid is a major and painful procedure.

This newer research has shown that these same two proteins can be found in the liquid that fills your eyeball. Getting that fluid of course…well, the image of jabbing my eyeball with a syringe is, to say the least, disquieting…

But, the amount needed is miniscule and is routinely collected during such things as cataract surgery, Lasix, and other perfectly unexciting eye procedures; so me getting shivering willies at the thought of needles and eyeballs is just a “me thing”!

The researchers conclude, “Neurofilament light chain (“strings” of molecules found in nerves) (NfL) is a promising biomarker of neurodegeneration in the cerebrospinal fluid and blood. This study investigated the presence of NfL in the vitreous humor and its associations with beta amyloid, tau proteins (as well as inflammatory cytokines and vascular proteins, apolipoprotein genotypes, Mini-Mental State Examination (MMSE) scores, systemic disease, and ophthalmic diseases.

“To run the tests, undiluted vitreous fluid was removed from the eyeball, and whole blood was drawn for genotyping. NfL, amyloid beta, total tau proteins, inflammatory cytokines, chemokines, and vascular proteins in the vitreous were measured…[After the analysis, researchers discovered that] NfL was found in all 77 samples. NfL was not found to be associated with any eye conditions, any genetic disorder, mental health questionnaire scores, or any other disease …NfL levels were positively associated with increased vitreous levels of β amyloid and several tau proteins…NfL was not associated with patients’ clinical eye condition. [It was ONLY related to Alzheimer’s and Parkinson’s disease]." 

I’m looking to see if I can get into a further study regarding this test!

Resources: https://www.sciencedaily.com/releases/2020/09/200921135403.htm, https://www.alz.org/alzheimers-dementia/facts-figures#:~:text=More%20than%205%20million%20Americans%20of%20all%20ages%20have%20Alzheimer's,with%20Alzheimer's%20dementia%20in%202020, https://www.who.int/news-room/fact-sheets/detail/dementia, https://medlineplus.gov/genetics/gene/app/, https://www.brightfocus.org/alzheimers-disease/article/tau-protein-and-alzheimers-disease-whats-connection
Image: https://www.meduniwien.ac.at/web/fileadmin/_processed_/e/1/csm_shutterstock_142671010_4683b6bf13.jpg

Sunday, October 4, 2020

ENCORE #144! – Exercise Decreases Insulin Resistance!

From the first moment my wife discovered she had breast cancer in March of 2011, there was a deafening silence from the men I knew. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…That was four years ago – as time passed, people searching for answers stumbled across my blog and checked out what I had to say. The following entry first appeared in May of 2012.

Doctors harp on exercise.

Despite the harping – or in my case, perversely because of it – I avoid exercise like the plague.

Even so, as I read more and more sites promoting the “exercise makes you better if you have breast cancer” meme, I found that almost none of them give any kind of evidence as to WHY exercise fights cancer and promotes healing.

So I dug into the sites and finally found some evidence supporting this wild, “Do this one weird thing…” kind of meme. This week, it’s number 

1)                  Insulin resistance, hyperinsulinaemia, hyperglycaemia and type 2 diabetes have been linked to increased risk of breast, colon, pancreas and endometrial cancers. Physical activity decreases insulin resistance, reduces hyperinsulinaemia and reduces risk for diabetes, which could explain the link between increased physical activity and reduced risk for these cancers

I talked about the connection between insulin and breast cancer earlier (http://breastcancerreaper.blogspot.com/2012/03/exercise-reduces-estrogen-in-blood-and.html), so I’ll talk more about EXERCISE here.

But before I go on, I’d like to say something about “non-exercise exercise”. My wife and hero works with kindergartners all day long: teaching reading, going out to recess, going to lunch, chasing down stragglers and generally corralling the little munchkins so much that she comes home with aching feet.

My question has always been: at what point does what I DO in everyday life become exercise?

There are advocates of daily exercise that explain: “We don't expend energy doing anything. We've actually engineered regular daily physical activity out of our lives…He says a lot of things stop us from burning calories…We come to work in almost any vocation and we sit. And we sit for eight hours and then we get up and we sit in the motorcar, you know, in automobile and we go home. When we arrive at home, we sit in front of the television. We have frozen TV dinners. We have pre-prepared, prepackaged food that doesn't require energy to collect it. We don't hunt, cook it. It's mostly just put in microwaves and simple systems…We don't even chop vegetables anymore. Bauman says that's very different from the way life used to be. He cites research by a colleague who studied people living and working in a historical Australian village, recreating life in the 19th century…Their energy expenditures were three to five times the amount that people spend today. And that was just a regular person going to and from work. It wasn't a lumberjack or someone who was working on the land or someone who had a huge heavily physical job…And, of course, three to five times more energy expenditure burns a lot more calories… Physical inactivity is a major risk factor for death and for illness. It contributes to about one-sixth of heart disease, cardiovascular disease, about the same for diabetes, about 12 percent for falls in the elderly, and about a tenth of all breast cancer and colon cancer are attributable to being physically inactive.” (Interview, Bauman/Silberner)

But what if my wife isn’t DOING that? Is what she DOES every day considered “exercise”?

YES!

“Even if you don’t have a 15 or 30 minute window to dedicate to yoga or a bike ride, that doesn’t mean you can’t add physical activity to your day. If you're not ready to commit to a structured exercise program, think about physical activity as a lifestyle choice rather than a single task to check off your to-do list. Look at your daily routine and consider ways to sneak in activity here and there. Even very small activities can add up over the course of a day: Clean the house, wash the car, tend to the yard and garden, mow the lawn with a push mower, sweep the sidewalk or patio with a broom; bike or walk to an appointment rather than drive, banish all elevators and use the stairs, briskly walk to the bus stop then get off one stop early, park at the back of the lot and walk into the store or office, take a vigorous walk during your coffee break. Walk while you’re talking on your cell phone; walk or jog around the soccer field during your kid’s practice, make a neighborhood bike ride part of weekend routine, play tag with your children in the yard or play exercise video games. Walk the dog together as a family, or if you don’t have your own dog, volunteer to walk a dog from a shelter. Organize an office bowling team, take a class in martial arts, dance, or yoga with a friend or spouse; gently stretch while watching your favorite show, do push-ups, sit-ups or lift light weights during the commercial breaks—you'll be amazed at how many repetitions you can fit in during the commercials of a half hour show! Better still, once a week turn off the TV and take a walk outside instead”

And the benefit of all they movement?

The very same ones as ANY form of exercise provides, and in this particular case, it results in an increased effectiveness of insulin in those who are insulin resistant!

So MOVE! If we can do it, so can you!

Resources: http://www.npr.org/templates/story/story.php?storyId=127525702, http://www.helpguide.org/life/exercise.htm