Saturday, August 30, 2014

GUY’S GOTTA TALK ABOUT…#6 Bone Density Scan...


http://www2.ipswichhospital.net/microsites/rheumatology/images/dxa_scanner_large.jpg

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

The word today is “osteoporosis”.

My wife just had a “bone density scan” done and the doctor said that the indications are that she has the beginning stages of this disease.

So I thought I’d take a step back and do a “translating the doctors” column.

First of all – why does the bone density of a breast cancer patient matter. (I won’t be using the last letter of the alphabet, a question mark or the mathematical symbol for nothing – they have stopped working.) At any rate, bone density matters: “Osteoporosis is a condition in which the bones become less dense and more likely to fracture.

Sounds simple enough. Factors that figure into the disease are on this site, too. The problem is that: “Women who have had breast cancer treatment may be at increased risk for osteoporosis and fracture for several reasons. First, estrogen has a protective effect on bone, and reduced levels of the hormone trigger bone loss…Studies suggest that chemotherapy also may have a direct negative effect on bone. In addition, the breast cancer itself may stimulate the production of osteoclasts, the cells that break down bone.”

In order to monitor patients during treatment and afterwards, doctors do something called a “bone scan”. What’s THAT mean (question mark)

Here’s a simple explanation of what happens: “The DXA (= Dual-energy X-ray Absorptiometry) machine sends a thin, invisible beam of low-dose x-rays with two distinct energy peaks through the bones being examined. One peak is absorbed mainly by soft tissue and the other by bone. The soft tissue amount can be subtracted from the total and what remains is a patient's bone mineral density…it feature[s a] special software to compute and display the bone density measurements on a computer monitor.

The question now is does this mean you should panic – and the doctor’s advice is “NO!” While osteoporosis can’t be “cured”, you can take steps to lessen the effects. “Getting enough calcium and vitamin D is essential to building strong, dense bones when you're young and to keeping them strong and healthy as you age.”

And you do that by eating well “…food is the best source of calcium. Dairy products, such as low-fat and non-fat milk, yogurt and cheese are high in calcium. Certain green vegetables and other foods contain calcium in smaller amounts. Some juices, breakfast foods, soymilk, cereals, snacks, breads and bottled water have calcium that has been added. If you drink soymilk or another liquid that is fortified with calcium, be sure to shake the container well as calcium can settle to the bottom.”

In our case, my wife is planning to increase her calcium intake – while she uses the chocolate “calcium chews”, she’ll add in the foods.

So if SHE’S not panicking, no reason for anyone else to panic! Be smart and eat well and take the drugs prescribed. If we end up going that route, I’ll do another post. But for now, this is what we know!


Saturday, August 16, 2014

BREAST CANCER RESEARCH RIGHT NOW! 22: Removing A Protein From A Breast Cancer Cell Nearly Stops It From Metastasizing



http://www.bioscience.org/2009/v14/af/3408/fig4.jpg

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

 

Every month, I’ll be highlighting breast cancer research that is going on RIGHT NOW! Harvested from different websites, journals and podcasts, I’ll translate them into understandable English and share them with you. Today: http://www.sciencedaily.com/releases/2014/06/140603092602.htm

“So far there isn't a really good target that can cure breast cancer. The more we understand of cancer metastasis and the pathways that control it, the better we will be able to stop breast cancer from spreading.”

While not EVERY woman treated for breast cancer experiences metastasizing tumors – which means that the initial breast cancer breaks up and sends cells to colonize the rest of the body – this is a worry for EVERY breast cancer diagnosis. Diagnosis and identification of metastasizing cancer is one of the reasons for regular checkups following mastectomy, chemo, and radiation. There is no way to know if a cancer has spread until it actually begins to show itself.

While breast cancer is often localized and stays in breast tissue and is treated there, no one was certain what exactly caused it to abruptly leave that tissue and begin to grow elsewhere.

Scientists have now identified a protein found in breast cancer cells that likely causes cells that usually remain in one place to go out into the rest of the body. With the daunting name of heterogeneous nuclear ribonucleoprotein M, hnRNPM is a protein-coding gene. Diseases associated with HNRNPM include impetigo, and treacher collins syndrome. The gene allows for the creation of a protein that “acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction...tumor necrosis...”

In other words, the gene they’ve discovered in breast cancer cells makes a protein that causes the cell to leave breast tissue and attach itself to other body organs and begin growing there – this is the definition of metastasizing.

Cause for celebration?

Not yet, but identifying something is the first step in being able to deal with it: “‘This confirmed hnRNPM's role in the metastasis of human breast cancer,’ Cheng said. ‘Now we're investigating how the protein works in order to be able to develop a drug that could prevent tumor metastasis.’”