Saturday, January 28, 2017

GUY’S GOTTA TALK ABOUT #32… Breast Cancer: Liberia

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

Liberia...

The vast majority of deaths from malignancies occur in sub-Saharan Africa primarily as a result of lack of public awareness of cancer and how it is diagnosed and treated in the setting of a severe lack of resources (physical and personnel) to actually diagnose tumors. To correct this massive health disparity, a plan of action is required across the continent of Africa to bring diagnostic medicine into the modern era and connect patients with the care they desperately need. - See more at: http://www.liberianobserver.com/health/%E2%80%98breast-cancer-curable%E2%80%99

Why should this matter to you? Why should the matter to me?

I COULD wallow in guilt. That would be both easy and satisfying! Instead, I’ve decided I’m going to take a character I’ve created in a science fiction short story, and send him on a few adventures. Most likely, he’ll be travelling with a hard-thinking woman who will become his perfect match. They’ve already started out rebuilding the educational infrastructure of Liberia in the future middle of this century. I’m thinking the two of them need to make a trip to Liberia. Separately – where they’ll meet and butt heads.

The driving issue will be breast cancer education, diagnosis, and treatment in these three West African countries that hold a special place in my heart. From the sale of the stories, I’ll donate the money to breast cancer research in those places…

Liberia suffered through a horrendous time of civil war, starting three years after I left. The First Liberian Civil War lasted seven years, followed by two years of semi-peace, and then the Second Liberian Civil which lasted for four more years until the women of the country told both sides, “Enough is enough. Be done.”

I can only imagine more than public marches and protests were brought to bear on the men of the country to quit their war. As a result, a woman was elected president and in recent history met with Michelle Obama.

As for progress against breast cancer – well, that’s slow. Most of the country’s infrastructure had been smashed. Even when I was there, the JFK Medical Center had become run down. Apparently it was used by both rebel forces and by international medical personnel during the wars. Of its original four institutions only three remain.

As well, breast cancer detection and treatment face two main hurdles – the first is awareness. When we visited, I think it’s safe to say that medical care in the three countries was roughly equivalent to what we could get in the US in the late 1950s. That include cancer awareness. In the 1950s, cigarette companies touted the fact that “More doctors smoke Camels than any other cigarette” (http://360jokes.com/wp-content/uploads/2011/07/more-doctors-smoke-camels.jpg) Breast cancer was spoken of in hushed voices – if it was talked about at all – because it involved, you know…BREASTS. Despite Howard Hughes, or perhaps because of him, breasts had become dirty and you certainly didn’t talk about them in public!

The attitude toward breasts in Liberia today is similar. But an equally huge issue is treatment of cancers that people DO have. I have documented in this blog the cost it took to rid my wife of cancer. I’ve continued to write because despite the fact that she is five-years-cancer-free, there are countless things she has to deal with as a result. Even here, the divorce/break up rate among women diagnosed with breast cancer has never been studied – though one study found that there was no correlation (https://academic.oup.com/jnci/article/91/1/54/2549274/Marital-Stability-After-Breast-Cancer), it involved a group that may have typically been stable anyway. Clearly more research is needed so that more effective supports might be put in place. I cannot imagine that Liberian men whose wives, fiancés, or girlfriends are diagnosed with breast cancer can find much community support!

At any rate, this is an area that needs study and support for the men and women involved.

Lastly, the kinds of treatment we have available here is most likely unavailable to your average Liberian woman…

Breakthrough, anyone?


Saturday, January 21, 2017

ENCORE #54! – Breast Cancer RAGE

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…That was four years ago – as time passed, people searching for answers stumbled across my blog and checked out what I had to say. The following entry appeared in February of 2014…
From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

Many of you saw this on Face Book a few [years] ago:

Then you followed the obscene requests by numerous individuals who thought that, while pictures of naked women, scantily clad women, women posing suggestively, and pure porn on Face Book is OK, fine, very fine, wonderful, just what I needed, and all in fun; women showing the results of breast cancer surgery was “naughty”.

You cannot imagine my rage – though some people could because there was such a back whiplash that I hope the people who thought that the bravery of this woman was obscene have to pick their heads up down the street.

Everyone knows but no one says that if she had posted a photo of herself PRIOR to her surgeries that the number of downloads would have busted Face Book’s servers.

The Face Book corporation FINALLY got it right: “The social networking site has left the images intact, however, because their intent is clearly educational and not sexual in nature (although Facebook famously hasn't been so supportive of mastectomy patients in the past).”

I applaud this woman with every ounce of my spirit. I applaud Face Book for making the right choice.

Words fail me when I contemplate the inhuman monsters who cried “inappropriate” and those who defriended this woman – the very same people who had friended her…I’d written something else here but I don’t think that it can go on Face Book, either…prior to her surgeries.

Sometimes Humanity appalls me. Then I think of the bravery of Beth Whaanga, of my wife, of the millions of other breast cancer survivors and their support groups…and I relax, realizing that there ARE many good people in this world.


Saturday, January 14, 2017

BREAST CANCER RESEARCH RIGHT NOW! #51: Breast Cancer Cells are Like STEM CELLS???!!!!

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…

Every month, I’ll be highlighting breast cancer research that is going on RIGHT NOW! Harvested from different websites, journals and podcasts, I’ll translate them into understandable English and share them with you. Today: http://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0712-6

The very first sentence was startling to me!

“Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.”

WTH is a “stem cell disease”?

Googling it was pointless because all it turned up was USES of stem cells to cure this, that, and the other thing. Not that they CAN do that yet, but the potential is there and scientists are working tirelessly to find out exactly how to use them to cure diseases like diabetes, spinal cord injury, Parkinson’s, Alzheimer’s, heart disease, Lou Gehrig’s, lung, arthritis, sickle cell, and organ failure.

Deeper digging brought me to this: “Most cancers are now viewed to be driven by a population of cells with stem cell characteristics…The subversion of molecular ‘stemness’ is now seen as a critical milestone, leading to oncogenesis.” Molecular Pathology of Hematolymphoid Diseases edited by Cherie H. Dunphy [https://books.google.com/books?id=t5Wt0BeldmAC&pg=PA8&lpg=PA8&dq=define:+cancer+is+now+viewed+as+a+stem+cell+disease&source=bl&ots=J5OZNr62od&sig=n4OhxvyDatzcC8ULJGIZed13Kh0&hl=en&sa=X&ved=0ahUKEwjQoMun_MLRAhVS72MKHSalBoMQ6AEIQzAG#v=onepage&q=define%3A%20cancer%20is%20now%20viewed%20as%20a%20stem%20cell%20disease&f=false]

So what does that all mean?

The hoopla for years is due to the fact that “stem cells” are like…cells waiting to be told what to do. Usually, in the Human body, the cells are like this only for a short time. That’s why there was a horrendous fight over scientists insisting that the only place they could possibly get stem cells from is from Human embryos. Everyone was girding for a fight for their research funding…when all of a sudden, other scientists discovered that there were some of these “cells waiting to be told what to do” in every one of us! “Adult stem cells have been identified in many organs and tissues, including brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, heart, gut, liver, ovarian epithelium, and testis. They are thought to reside in a specific area of each tissue (called a "stem cell niche").” (https://stemcells.nih.gov/info/basics/4.htm).

Pretty much end-of-fight with egg on the faces of name-callers all around.

So – apparently, there are Cancer Stem Cells (CSCs) now. From the article I started with: “There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.”

WTH does THAT mean?

Essentially this – that there are stem cells waiting to change into active cancer cells. They need certain things, which nobody is certain of yet. It APPEARS that there are a couple of things they agree on.

First is that a cancer virus (?) can grab hold of the stem cell’s ability to change into whatever is needed – and turn it into a cancer cell. Second the suckers can ADAPT like crazy to whatever the body is doing around them. Acidity? No problem! Cold? No problem! Fever? No problem! The cancer cells welcome the challenge so that they might laugh at the Human body and begin to grow uncontrollably. The way they adapt is to shift their “power source”. Sort of like “Flex-Fuel” cars. Whatever energy they can get hold of, they use.

Sneaky SOBs, eh?

The future may hold new drugs that block the cancer cells from being able to switch power sources. As well, there are also non-stem cancer cells, so chemo may still be a normal cancer procedure. This research has primarily been looking at how to prevent cancer cells from metastasizing – but from that research…who knows what may grow?


Saturday, January 7, 2017

ENCORE #53! – “The doctor gave me a pill and I grew a new kidney!”

From the first moment my wife discovered she had breast cancer, there was a deafening silence from the men I know. Even ones whose wives, mothers or girlfriends had breast cancer seemed to have received a gag order from some Central Cancer Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this blog…That was four years ago – as time passed, people searching for answers stumbled across my blog and checked out what I had to say. The following entry appeared in July of 2014…I will ALSO add here that this is one of my favorite posts of all time!

(I am pre-posting this because MY DAUGHTER IS GETTING MARRIED TODAY!!!!)

I haven’t talked about STAR TREK yet, which isn’t like me at all!

ST was my favorite TV show growing up, as an adult and now as an “old guy”. During the opening week of the STAR TREK 2009 reboot, my dad (who introduced me to STAR TREK), me (a total ST fan) and my son (who grew up with ST and at whom the new movie was targeted) – went to see it. None of the wonder was gone and I love the NEW as much as all of the old.

At any rate, it got me to thinking about a scene from STAR TREK IV: The Voyage Home in which an elderly woman is laying on a hospital cot waiting to go in for dialysis:

McCoy: [McCoy, masked and in surgical garb, passes an elderly woman groaning on a gurney in the hallway] What's the matter with you?

Elderly patient: [weakly] Kidney [pause] dialysis.

McCoy: [genuinely surprised] Dialysis?[musing to himself] What is this, the Dark Ages? [He turns back to the patient and hands her a large white pill] Here, [pause] you swallow that, and if you have any more problems, just call me! [He pats her cheek and leaves]

…a few moments later…

Elderly patient: [the dialysis patient is being wheeled down the hall after being given the pill by McCoy] [joyfully] The doctor gave me a pill, and I grew a new kidney!


It made me wonder for two reasons. The first was that while today breast cancer survival rates are as high as 98% (for early detection and treatment), at one time tumors could only be detected when they could actually be felt – and then the ONLY treatment was radical mastectomy which, in the late 19th Century removed not only breast tissue but muscles and all lymph nodes as well. If a woman survived that, she was profoundly weakened and handicapped for the rest of her life.

The introduction of modified mastectomies (1950s), mammogram advances (starting in 1967), ultrasound (late 1970s), followed by MRIs, digital mammography, 3D mammography and increasingly refined chemotherapy (introduced in the 1940s), radiation (early 20th Century) and lumpectomies combined with radiation therapy (1970s) and most recently, hormonal treatment and genetic testing improved treatment – and subsequently survival rates.

I’m going to delve into the history of breast cancer later, but for now, let me just say that while it still terrifies me even now; I do have a daughter and hold VERY high hopes that either her or her daughter will someday be able to pop a pill and cry out, “The doctor gave me a pill and I’m cured of breast cancer!”