Saturday, May 6, 2017

GUY’S GOTTA TALK ABOUT…Alzheimer’s #7: The Science of Sundowning – Part 1

Dad’s diagnosis of Alzheimer’s stayed hidden from everyone until I took over the medical administration of my parents in 2015. Once I found out, there was a deafening silence from most of the people I know even though virtually all of them would add, “My _____ had Alzheimer’s…” But there was little help, little beyond people sadly shaking heads. Or horror stories. Lots of those. Even the ones who knew about the disease seemed to have received a gag order from some Central Alzheimer’s Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this part of my blog…

Dad’s sundowning is getting worse.

Last night he called me several times, confused in many ways. Once he insisted he wasn’t at the care facility where he has lived for the past two years. Another time he called asking me about a battery being charged. A third time he called worried about how he’d get to work tonight – and when I asked a bit for details he stumbled about somehow know BOTH that he’d been retired since 1993 and that he needed to get to work. When I wondered what he did there, he said, “Oh, whatever needs to be done.”

The last call was for me to come and get him and take him home – yet when I asked where, he said, “To the place I’m supposed to be.” We talked for some time, until I finally got him to agree that he’d stay there for the night and we’d talk in the morning…

As I often did when exploring my wife’s breast cancer, I pulled up a recent journal article and I’ll interpret what it says, “Neuropsychiatric symptoms (NPSs) are characterized by a marked interindividual variability. Their prevalence and severity change over the course of the disease. Moreover, multiple interacting variables and pathophysiological mechanisms may influence their occurrence and phenotypic expression. These aspects have been frequently hindering the application of standardized clinical and analytic approaches to NPS, as well as the identification of targeted pharmacological interventions.”

In essence, the authors are telling me that there are so many things that go into how an Alzheimer’s patient experiences sundowning, that there IS no standard treatment – because there is no “normal” expression of the disease. Because it’s so highly individualistic, “…the sundown syndrome has so far drawn limited clinical and scientific interest compared to other specific NPS and behavioral disturbances occurring in dementias (e.g., apathy, depression, psychotic symptoms). As a proof, the available data concerning its prevalence (mostly obtained in institutional/residential settings) are scarce and markedly discordant in the literature. Moreover, no randomized controlled trial (RCT) specifically investigating the effectiveness of pharmacological and non-pharmacological strategies in managing this condition among demented patients has been yet conducted. Several aspects may account for this low attention, such as the lack of commonly agreed definitions, the absence of specific screening and assessment tools and the multiplicity of factors that may trigger or affect its occurrence…the sundown syndrome does not appear in the recent fifth revision of the Diagnostic and Statistical Manual of Mental Disorders.”

To be perfectly frank with y’all, because there’s no target for a drug, no doctor or pharmaceutical company is going to pay for research because there’s no pot of gold at the end of Alzheimer’s rainbow. With nothing apparent to show a “dramatic recovery” when a patient gets a shot or pops a pill, no one is going to see if there’s anything to be done.

This attitude toward sundowning also reminds me of the state of education – there’s no clear definition of WHAT education is. There are very vague and woo-woo sounding ones, like this from Wikipedia: “Education is the process of facilitating learning, or the acquisition of knowledge, skills, values, beliefs, and habits….[it] frequently takes place under the guidance of educators, but learners may also educate themselves. Education can take place in formal or informal settings and any experience that has a formative effect on the way one thinks, feels, or acts may be considered educational.” Now if that isn’t vague, contradictory, and completely unhelpful, imagine what it’s like to try to justify what you do to your friends, community, and congressional bodies!

This appears to be that same for sundowning.

I’m going to stop now and continue with this discussion in future Alzheimer’s posts.

Later.


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