Saturday, December 31, 2016

GUY’S GOTTA TALK ABOUT…Alzheimer’s #4 – Magic Bullets?

Dad’s diagnosis of Alzheimer’s stayed hidden from everyone until I took over the medical administration of my parents in 2015. Once I found out, there was a deafening silence from most of the people I know even though virtually all of them would add, “My _____ had Alzheimer’s…” But there was little help, little beyond people sadly shaking heads. Or horror stories. Lots of those. Even the ones who knew about the disease seemed to have received a gag order from some Central Alzheimer’s Command and did little more than mumble about the experience. Not one to shut up for any known reason, I started this part of my blog…
This comes at a good time because the other day, my dad called me about some drug he’d seen advertised on late-night TV called “Cebria”. He said he was thinking about getting a supply of the drug because the advertising slogan is so…enticing: “Think Faster & Remember More with Cebria® Improve Your Memory in just 30 Days!**Results may vary!”

He knows he has Alzheimer’s and to the best of my estimation capabilities, he is in Stage 5 or 6 – if he’s in 6, he’s slipped into it recently. I just realized that I haven’t ever defined those stages. Here you go:

Stage 1: Alzheimer’s disease is not detectable and no memory problems or other symptoms of dementia are evident.

Stage 2: Minor memory problems like losing things around the house though indistinguishable from normal age related memory loss. Undetectable via testing.

Stage 3: Friends and family members begin to notice memory and cognitive problems. Physicians using tests can detect impaired cognitive function. The person can’t find the right word during conversation, forget names of new acquaintances, trouble planning and organizing, frequently lose personal possessions, including valuables.

Stage 4: Difficulty with simple arithmetic, forgetting details about life history, poor short term memory, inability to manage finances.

Stage 5: Need help with many day to day activities, significant confusion, inability to recall simple details about themselves (phone number, address, age); difficulty dressing appropriately; they DO maintain functionality: bathe and toilet independently; know family members and some detail about their personal histories.

Stage 6: Need constant supervision and frequently require professional care; confusion or unawareness of environment and surroundings; major personality changes and potential behavior problems; need assistance with activities of daily living; inability to recognize faces except closest friends and relatives; inability to remember most details of personal history; loss of bowel and bladder control; wandering

Stage 7: Alzheimer’s is terminal, patients in stage seven are nearing death. Lose ability to respond to their environment or communicate. While they may still be able to utter words and phrases, they have no insight into their condition and need assistance with all activities of daily living. In the final stages of the illness, patients may lose their ability to swallow.

Truth? I can’t imagine that “Cebria” or any other nootropic pill will make Dad remember any better. My biggest problem is that a person takes the pill and the first place it hits is the stomach. The hydrochloric acid in the stomach helps the molecules that break down food work better, the to “acidity” can vary between 1.5 to 5 (car battery acid up to acid rain). I can’t imagine the lactose, glutamic acid, lysine, leucine, arginine, aspartic acid, serine, phenylalanine, valine, threonine, tyrosine, isoleucine, histidine, methionine, and tryptophan (the ingredients of the pill: http://www.topcognitiveenhancers.com/nootropic-reviews-seniors/cebria) will last long in the stomach. Moreover, I can’t imagine that they will then be taken up by the bloodstream and passed to the brain – which has a barrier set up specifically to filter out “junk”. OK – so according to Wikipedia, it DOES allow the passage of amino acids through the barrier (“ The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function.”)

The fact is that these nootropic companies are in direct competition with real medicine – which can’t find a cure (or even an effective treatment) of Alzheimer’s. The niche is open at this moment and there’s a mad scramble to make a buck any way possible. I include Big Pharma in that scramble as well…

HOWEVER…as I’ve started to realize in my writing: “Evil” forces – especially in Humans – rarely view THEMSELVES as evil. They’re just trying to find a solution to a problem they perceive as life-threatening. While I am sure that there are drug manufacturers whose sole goal is to rake in untold wealth while not caring a fig about the destruction they leave in their wake; most of these companies “sincerely believe” that they are doing good.

And therein lies the tale…

Image:  http://az616578.vo.msecnd.net/files/2016/06/25/6360242025150255191939281878_Alzheimer-disease-patients.jpg

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